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Article

The penetrance of ductal carcinoma in situ among BRCA1 and BRCA2 mutation carriers.

Breast cancer research and treatment - 1 Jan 2013

Mazzola Emanuele, Cheng Su-Chun, Parmigiani Giovanni

Abstract excerpt

Ductal carcinoma in situ (DCIS) is a precancerous lesion of the female breast and is strongly suspected to be a precursor of invasive breast cancer (IBC). Our goal is the estimation of the age-specific and lifetime penetrances of DCIS among carriers of either a BRCA1 or BRCA2 deleterious mutation. We jointly re-analyze the SEER9 database and a previous study by Claus et al. (JAMA 293:964-969, 2005). Estimation is...

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Source

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Identifiers

PMID: 23184082
DOI: 10.1007/s10549-012-2345-5
PMCID: PMC3836600

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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