Article
Androgen receptor GGC polymorphism and testosterone levels associated with high risk of prostate cancer and benign prostatic hyperplasia.
Molecular biology reports - 1 Mar 2013
Biolchi Vanderlei, Silva Neto Brasil, Pianta Diego Bromfman, Koff Walter José, Berger Milton, Brum Ilma Simoni
Abstract excerpt
Polymorphic GGC repeats in the androgen receptor (AR) gene can alter transactivation of androgen-responsive genes and increase the risk of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). We investigated the association between GGC repeat length, testosterone levels and the risk of developing PCa and BPH in a population from southern Brazil. A sample comprising 130 PCa, 126 BPH and 88 control...
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