Article
Linkage disequilibrium and heritability of copy-number polymorphisms within duplicated regions of the human genome.
American journal of human genetics - 1 Aug 2006
Locke Devin P, Sharp Andrew J, McCarroll Steven A, McGrath Sean D, Newman Tera L, Cheng Ze, Schwartz Stuart, Albertson Donna G, Pinkel Daniel, Altshuler David M, Eichler Evan E
Abstract excerpt
Studies of copy-number variation and linkage disequilibrium (LD) have typically excluded complex regions of the genome that are rich in duplications and prone to rearrangement. In an attempt to assess the heritability and LD of copy-number polymorphisms (CNPs) in duplication-rich regions of the genome, we profiled copy-number variation in 130 putative "rearrangement hotspot regions" among 269 individuals of...
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