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Deficiency of the multi-copy mouse Y gene <i>Sly</i> causes sperm DNA damage and abnormal chromatin packaging

1 Jan 2012

Abstract excerpt

In mouse and man Y chromosome deletions are frequently associated with spermatogenic defects. Mice with extensive deletions of non-pairing Y chromosome long arm (NPYq) are infertile and produce sperm with grossly misshapen heads, abnormal chromatin packaging and DNA damage. The NPYq-encoded multi-copy gene Sly controls the expression of sex chromosome genes after meiosis and Sly deficiency results in a remarkable...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 23178944
DOI: 10.1242/jcs.114488

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