Article
Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole.
BMC plant biology - 24 Nov 2012
Schreiber Karl J, Austin Ryan S, Gong Yunchen, Zhang Jianfeng, Fung Pauline, Wang Pauline W, Guttman David S, Desveaux Darrell
Abstract excerpt
BACKGROUND: The sulfanilamide family comprises a clinically important group of antimicrobial compounds which also display bioactivity in plants. While there is evidence that sulfanilamides inhibit folate biosynthesis in both bacteria and plants, the complete network of plant responses to these compounds remains to be characterized. As such, we initiated two forward genetic screens in Arabidopsis in order to...
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