Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isolation and characterisation of an antifolate insensitive (afi1) mutant of Arabidopsis thaliana.

Plant biology (Stuttgart, Germany) - 1 Jan 2013

Navarrete O, Van Daele J, Stove C, Lambert W, Storozhenko S, Van Der Straeten D

Abstract excerpt

Antifolates can impair the synthesis and/or function of folates in living organisms. Mechanisms of resistance or tolerance to antifolates have been mainly described in plants using the drug methotrexate. In this work, the antifolate trimethoprim (TMP) was used with the aim of revealing a novel mechanism of resistance. EMS mutagenised seeds from Arabidopsis were screened to isolate individuals insensitive to TMP....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Plant
Share to Folic Acid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Folic Acid Antagonists

Share to Methotrexate

Share to Seedlings

Share to Tetrahydrofolate Dehydrogenase

Share to Trimethoprim

Share to Up-Regulation

Source

Identifiers

PMID: 22672761
DOI: 10.1111/j.1438-8677.2012.00602.x

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isolation and characterisation of an antifolate insensitive (afi1) mutant of Arabidopsis thaliana.PMID 22672761Read ↗

A fluoroorotic acid-resistant mutant of Arabidopsis defective in the uptake of uracil.Semantic proximity Read ↗

MTHFD1 controls DNA methylation in Arabidopsis.Semantic proximity Read ↗

Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole.Semantic proximity Read ↗

Molecular characterization and inheritance of resistance to ACCase-inhibiting herbicides in Lolium rigidum.Semantic proximity Read ↗

An Arabidopsis mutant that is resistant to the protoporphyrinogen oxidase inhibitor acifluorfen shows regulatory changes in tetrapyrrole biosynthesis.Semantic proximity Read ↗

Insights into the Role of Transcriptional Gene Silencing in Response to Herbicide-Treatments in Arabidopsis thaliana.Semantic proximity Read ↗

The analysis of the ChlI 1 and ChlI 2 genes using acifluorfen-resistant mutant of Arabidopsis thaliana.Semantic proximity Read ↗

Folate shapes plant root architecture by affecting auxin distribution.Semantic proximity Read ↗

Enhanced rates of herbicide metabolism in low herbicide-dose selected resistant Lolium rigidum.Semantic proximity Read ↗

Dinitroaniline herbicide resistance in a multiple-resistant Lolium rigidum population.Semantic proximity Read ↗

Arabidopsis ALF5, a multidrug efflux transporter gene family member, confers resistance to toxins.Semantic proximity Read ↗

Characterization of a novel developmentally retarded mutant (drm1) associated with the autonomous flowering pathway in Arabidopsis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.