Article
Clinical, histopathological and genetic studies in a family with fatal familial insomnia.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2010
Shi Xiao-Hong, Han Jun, Zhang Jin, Shi Qi, Chen Jian-Ming, Xia Sheng-Li, Xie Zhi-Qiang, Shen Xiao-Jing, Shan Bing, Lei Yan-Jun, Shi Song, Zhou Wei, Zhang Bao-Yun, Gao Chen, Liu Ying-Hui, Song Juan, Guo Yan-Jun, Wang De-Xin, Xu Bian-Li, Dong Xiao-Ping
Abstract excerpt
We compared clinical data from two related Chinese patients with fatal familial insomnia (FFI) and collected information about their pedigree. The clinical features in the two cases were similar and included initial progressive insomnia and sympathetic activation, which persisted throughout the clinical course. A total of 135 members of this family, across seven generations, were retrospectively investigated....
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