Article
Effect of genetic polymorphisms on effectiveness of low-dose azathioprine in Japanese patients with systemic lupus erythematosus.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists - 1 Dec 2012
Nagamine Ayumu, Takenaka Miki, Aomori Tohru, Okada Yuko, Hiromura Keiju, Nojima Yoshihisa, Araki Takuya, Nakamura Tomonori, Yamamoto Koujirou
Abstract excerpt
PURPOSE: The effect of genetic polymorphisms on the effectiveness of low-dose azathioprine in Japanese patients with systemic lupus erythematosus (SLE) was studied. METHODS: Sixty-one unrelated Japanese patients with SLE treated with azathioprine were included in the study. The selected genetic polymorphisms evaluated in the analysis were ITPA 138G>A, ITPA 563G>A, IMPDH 1575A>G, XO 837C>T, XO 2211C>T, XO 3030C>T,...
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