Article
Evidence for possible non-canonical pathway(s) driven early-onset colorectal cancer in India.
Molecular carcinogenesis - 1 Feb 2014
Raman Ratheesh, Kotapalli Viswakalyan, Adduri Raju, Gowrishankar Swarnalata, Bashyam Leena, Chaudhary Ajay, Vamsy Mohana, Patnaik Sujith, Srinivasulu Mukta, Sastry Regulagadda, Rao Subramanyeshwar, Vasala Anjayneyulu, Kalidindi NarasimhaRaju, Pollack Jonathan, Murthy Sudha, Bashyam Murali
Abstract excerpt
Two genetic instability pathways viz. chromosomal instability, driven primarily by APC mutation induced deregulated Wnt signaling, and microsatellite instability (MSI) caused by mismatch repair (MMR) inactivation, together account for >90% of late-onset colorectal cancer (CRC). Our understanding of early-onset sporadic CRC is however comparatively limited. In addition, most seminal studies have been performed in...
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