Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prognostic and therapeutic relevance of c‐<scp>FLIP</scp> in acute myeloid leukaemia

20 Nov 2012

Abstract excerpt

Chemoresistance is a major contributor to the aggressiveness of AML and is often due to insufficient apoptosis. The CFLAR gene is expressed as long and short splice forms encoding the anti-apoptotic proteins c-FLIP(L) and c-FLIP(S) (CFLAR(L) and CFLAR(S) , respectively) that play important roles in drug resistance. In univariate analyses of CFLAR mRNA expression in adult AML patients, those individuals with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Cell death mechanisms and regulation
Share to Chronic Myeloid Leukemia Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23167276
DOI: 10.1111/bjh.12108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic and therapeutic relevance of c‐<scp>FLIP</scp> in acute myeloid leukaemiaPMID 23167276Read ↗

Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer TherapySemantic proximity Read ↗

FLIP as a therapeutic target in cancerSemantic proximity Read ↗

FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanismSemantic proximity Read ↗

The Study of SRSF1 Regulates Abnormal Alternative Splicing of BCL2L11 and the Role in Refractory Acute Myeloid Leukemia.Semantic proximity Read ↗

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death.Semantic proximity Read ↗

A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein.Semantic proximity Read ↗

Cellular FLICE-inhibitory protein (c-FLIP) signalling: A key regulator of receptor-mediated apoptosis in physiologic context and in cancerSemantic proximity Read ↗

The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patientsSemantic proximity Read ↗

Activated Intrinsic Apoptosis Pathway Is a Key Related Prognostic Parameter in Acute Myeloid LeukemiaSemantic proximity Read ↗

FLIP as an Anti-Cancer Therapeutic TargetSemantic proximity Read ↗

Characterization of the Human FLICE‐Inhibitory Protein Locus and Comparison of the Anti‐Apoptotic Activity of Four Different FLIP IsoformsSemantic proximity Read ↗

The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR MutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.