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Sonic hedgehog-Dependent Induction of MicroRNA 31 and MicroRNA 150 Regulates <i>Mycobacterium bovis</i> BCG-Driven Toll-Like Receptor 2 Signaling

20 Nov 2012

Abstract excerpt

Hedgehog (HH) signaling is a significant regulator of cell fate decisions during embryogenesis, development, and perpetuation of various disease conditions. Testing whether pathogen-specific HH signaling promotes unique innate recognition of intracellular bacteria, we demonstrate that among diverse Gram-positive or Gram-negative microbes, Mycobacterium bovis BCG, a vaccine strain, elicits a robust activation of...

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PMID: 23166298
DOI: 10.1128/mcb.01108-12

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