Association of fetal but not maternal P-glycoprotein C3435T polymorphism with fetal growth and birth weight, a possible risk factor for cardiovascular diseases in later life.

Abstract excerpt

BACKGROUND: The multidrug transporter P-glycoprotein (PGP) is expressed in the human placenta. In particular the C3435T ABCB1 polymorphism was associated with altered tissue expression of PGP in the human placenta. However, the potential functional impact of this polymorphism on the offspring is unknown so far. METHODS: We analyzed the impact of the ABCB1/C3435T polymorphism on fetal growth in 262 mother/child...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to ATP Binding Cassette Transporter, Subfamily B
• Share to ATP Binding Cassette Transporter, Subfamily B, Member 1