Article
African ancestry and genetic risk for uterine leiomyomata.
American journal of epidemiology - 15 Dec 2012
Wise Lauren A, Ruiz-Narvaez Edward A, Palmer Julie R, Cozier Yvette C, Tandon Arti, Patterson Nick, Radin Rose G, Rosenberg Lynn, Reich David
Abstract excerpt
Rates of uterine leiomyomata (UL) are 2-3 times higher in African Americans than in European Americans. It is unclear whether inherited factors explain the ethnic disparity. To investigate the presence of risk alleles for UL that are highly differentiated in frequency between African Americans and European Americans, the authors conducted an admixture-based genome-wide scan of 2,453 UL cases confirmed by...
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