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p53-Independent Abrogation of a Postmitotic Checkpoint Contributes to Human Papillomavirus E6 -Induced Polyploidy

15 Mar 2007

Abstract excerpt

Polyploidy is often an early event during cervical carcinogenesis, and it predisposes cells to aneuploidy, which is thought to play a causal role in tumorigenesis. Cervical and anogenital cancers are induced by the high-risk types of human papillomavirus (HPV). The HPV E6 oncoprotein induces polyploidy in human keratinocytes, yet the mechanism is not known. It was believed that E6 induces polyploidy by abrogating...

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PMID: 17363579
DOI: 10.1158/0008-5472.can-06-3436

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p53-Independent Abrogation of a Postmitotic Checkpoint Contributes to Human Papillomavirus E6 -Induced PolyploidyPMID 17363579Read ↗

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