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Article

Identification of a novel gene fusion RNF213-SLC26A11 in chronic myeloid leukemia by RNA-Seq

13 Nov 2012

Abstract excerpt

Chronic myeloid leukemia (CML) was the first hematological malignancy to be associated with a specific genetic lesion. The Philadelphia translocation, producing a BCR‑ABL hybrid oncogene, is the most common mechanism of CML development. However, in the present study, b3a2, b2a2 and ela2 fusion junctions of the breakpoint cluster region (BCR)-V-abl Abelson murine leukemia viral oncogene homolog 1 (ABL) gene were...

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Identifiers

PMID: 23151810
DOI: 10.3892/mmr.2012.1183

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