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Article

Functional Characterization of a Ficolin-mediated Complement Pathway in Amphioxus

9 Aug 2011

Abstract excerpt

The ficolin-mediated complement pathway plays an important role in vertebrate immunity, but it is not clear whether this pathway exists in invertebrates. Here we identified homologs of ficolin pathway components from the cephalochordate amphioxus and investigated whether they had been co-opted into a functional ficolin pathway. Four of these homologs, ficolin FCN1, serine protease MASP1 and MASP3, and complement...

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PMID: 21832079
DOI: 10.1074/jbc.m111.245944

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