Relationships between sequestration, antigenic variation and chronic parasitism in <i>Plasmodium chabaudi chabaudi</i>– a rodent malaria model

Abstract excerpt

We describe here a rodent malaria model using cloned lines of Plasmodium chabaudi chabaudi in inbred CBA/Ca mice that exhibits both clonal antigenic variation in late stage-specific surface antigens, and deep vascular schizogony in the liver. We show that both these features are modulated by the spleen, and that surface antigen expression is crucially involved in the sequestering phenotype. Surface antigens are...