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Yeast screens for host factors in positive-strand RNA virus replication based on a library of temperature-sensitive mutants.

Methods (San Diego, Calif.) - 1 Feb 2013

Nawaz-ul-Rehman Muhammad Shah, Reddisiva Prasanth K, Baker Jannine, Nagy Peter D

Abstract excerpt

RNA viruses exploit host cells by altering cellular pathways, recruiting host factors, remodeling intracellular membranes and escaping host antiviral responses. Model hosts, such as Saccharomyces cerevisiae (yeast), are valuable to identify host factors involved in viral RNA replication. The many advantages of using yeast include the availability of various yeast mutant libraries, such as (i) single gene-deletion...

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PMID: 23147170
DOI: 10.1016/j.ymeth.2012.11.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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