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Article

RNA virus replication depends on enrichment of phosphatidylethanolamine at replication sites in subcellular membranes

25 Mar 2015

Abstract excerpt

Intracellular membranes are critical for replication of positive-strand RNA viruses. To dissect the roles of various lipids, we have developed an artificial phosphatidylethanolamine (PE) vesicle-based Tomato bushy stunt virus (TBSV) replication assay. We demonstrate that the in vitro assembled viral replicase complexes (VRCs) in artificial PE vesicles can support a complete cycle of replication and asymmetrical...

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PMID: 25810252
DOI: 10.1073/pnas.1418971112

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