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Article

Translation elongation factor 1A facilitates the assembly of the tombusvirus replicase and stimulates minus-strand synthesis.

PLoS pathogens - 4 Nov 2010

Li Zhenghe, Pogany Judit, Tupman Steven, Esposito Anthony M, Kinzy Terri Goss, Nagy Peter D

Abstract excerpt

Replication of plus-strand RNA viruses depends on host factors that are recruited into viral replicase complexes. Previous studies showed that eukaryotic translation elongation factor (eEF1A) is one of the resident host proteins in the highly purified tombusvirus replicase complex. Using a random library of eEF1A mutants, we identified one mutant that decreased and three mutants that increased Tomato bushy stunt...

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Identifiers

PMID: 21079685
DOI: 10.1371/journal.ppat.1001175
PMCID: PMC2973826

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Translation elongation factor 1A facilitates the assembly of the tombusvirus replicase and stimulates minus-strand synthesis.PMID 21079685Read ↗

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