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HERV-E-Mediated Modulation of PLA2G4A Transcription in Urothelial Carcinoma

7 Nov 2012

Abstract excerpt

Human endogenous retroviruses (HERV) and related elements account for more than 8% of the human genome and significantly contribute to the human transcriptome by long terminal repeat (LTR) promoter activity. In this context, HERVs are thought to intervene in the expression of adjacent genes by providing regulatory sequences (cis-effect) or via noncoding RNA including natural antisense transcripts. To address the...

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PMID: 23145155
DOI: 10.1371/journal.pone.0049341

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