P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.

doi:10.1164/rccm.201204-0750OC

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Article

P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.

American journal of respiratory and critical care medicine - 1 Jan 2013

Denlinger Loren C, Manthei David M, Seibold Max A, Ahn Kwangmi, Bleecker Eugene, Boushey Homer A, Calhoun William J, Castro Mario, Chinchili Vernon M, Fahy John V, Hawkins Greg A, Icitovic Nicolina, Israel Elliot, Jarjour Nizar N, King Tonya, Kraft Monica, Lazarus Stephen C, Lehman Erik, Martin Richard J, Meyers Deborah A, Peters Stephen P, Sheerar Dagna, Shi Lei, Sutherland E Rand, Szefler Stanley J, Wechsler Michael E, Sorkness Christine A, Lemanske Robert F

Abstract excerpt

RATIONALE: The function of the P2X(7) nucleotide receptor protects against exacerbation in people with mild-intermittent asthma during viral illnesses, but the impact of disease severity and maintenance therapy has not been studied. OBJECTIVES: To evaluate the association between P2X(7), asthma exacerbations, and incomplete symptom control in a more diverse population. METHODS: A matched P2RX7 genetic...

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PMID: 23144325
DOI: 10.1164/rccm.201204-0750OC
PMCID: PMC3570642

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