Article
The p150 subunit of dynactin (DCTN1) gene in multiple sclerosis.
Acta neurologica Scandinavica - 1 Oct 2007
Münch C, Meyer R, Linke P, Meyer T, Ludolph A C, Haas J, Hemmer B
Abstract excerpt
OBJECTIVES: Mutations in the p150 subunit of the axonal transport protein dynactin (DCTN1) have been reported in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Given the common features of neurodegeneration in multiple sclerosis (MS), FTD and ALS, sequence variants of the DCTN1 gene may be a contributory factor to neurodegeneration in MS. METHODS: We investigated a total of...
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