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Article

Low phospholipid-associated cholestasis and cholelithiasis.

Clinics and research in hepatology and gastroenterology - 1 Sept 2012

Erlinger Serge

Abstract excerpt

Low phospholipid-associated cholestasis and cholelithiasis (LPAC) is a genetic disorder characterized by cholesterol gallbladder and intrahepatic stones. It is caused by a mutation of the gene ABCB4, which encodes the canalicular protein ABCB4/MDR3, a flippase that plays an essential role in the secretion of phosphatidylcholine into bile. Failure of this protein leads to secretion of bile that is poor in...

Read the complete abstract on PubMed

Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diagnosis, Differential

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Share to Pregnancy Complications

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Source

Identifiers

PMID: 23141892
DOI: 10.1016/S2210-7401(12)70019-0

Genes

ABCB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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