Article
Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.
International journal of cancer - 1 Jun 2013
Chan Paul K S, Zhang Chuqing, Park Jong-Sup, Smith-McCune Karen K, Palefsky Joel M, Giovannelli Lucia, Coutlée Francois, Hibbitts Samantha, Konno Ryo, Settheetham-Ishida Wannapa, Chu Tang-Yuan, Ferrera Annabelle, Alejandra Picconi María, De Marco Federico, Woo Yin-Ling, Raiol Tainá, Piña-Sánchez Patricia, Bae Jeong-Hoon, Wong Martin C S, Chirenje Mike Z, Magure Tsitsi, Moscicki Anna-Barbara, Fiander Alison N, Capra Giuseppina, Young Ki Eun, Tan Yi, Chen Zigui, Burk Robert D, Chan Martin C W, Cheung Tak-Hong, Pim David, Banks Lawrence
Abstract excerpt
Human papillomavirus (HPV) 58 accounts for a notable proportion of cervical cancers in East Asia and parts of Latin America, but it is uncommon elsewhere. The reason for such ethnogeographical predilection is unknown. In our study, nucleotide sequences of E6 and E7 genes of 401 HPV58 isolates collected from 15 countries/cities across four continents were examined. Phylogenetic relationship, geographical...
Topics
- Biomarkers, Tumor
- Capsid Proteins
- Cervix Uteri
- DNA, Neoplasm
- Female
- Follow-Up Studies
- Genetic Variation