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Article

Metabolic profile, enzyme kinetics, and reaction phenotyping of β-lapachone metabolism in human liver and intestine in vitro.

Molecular pharmaceutics - 3 Dec 2012

Cheng Xuefang, Liu Fang, Yan Tingting, Zhou Xueyan, Wu Liang, Liao Ke, Wang Guangji, Hao Haiping

Abstract excerpt

β-Lapachone (β-Lap) is an NAD(P)H: quinone oxidoreductase 1 (NQO1) target antitumor drug candidate in phase II clinical trials. The present study aimed to uncover the metabolic profile, enzyme kinetics, and enzyme isoforms for the metabolism of β-Lap in human liver and intestine in vitro. NQO1-mediated quinone reduction and subsequent glucuronidation is the predominant metabolic pathway for β-Lap in humans; a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23134532
DOI: 10.1021/mp300296m

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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