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Article

FRET-Assisted Determination of CLN3 Membrane Topology

22 Jul 2014

Abstract excerpt

Juvenile neuronal ceroid lipofuscinosis (JNCL) is caused by mutations in the CLN3 gene, which encodes for a putative lysosomal transmembrane protein with thus far undescribed structure and function. Here we investigate the membrane topology of human CLN3 protein with a combination of advanced molecular cloning, spectroscopy, and in silico computation. Using the transposomics cloning method we first created a...

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PMID: 25051496
DOI: 10.1371/journal.pone.0102593

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