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AAV Infection: Protection from Cancer

10 Nov 2016

Abstract excerpt

There are conflicting reports that integration of the wild-type adeno-associated virus 2 (AAV2) genome is associated with induction of hepatocellular carcinoma (HCC) in a small subset of patients. However, there are several lines of evidence that contradict this assertion: (i) AAV2 has long been known to be a non-pathogenic virus, although ∼90% of the human population is seropositive for AAV2 antibodies; (ii)...

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PMID: 27832705
DOI: 10.1089/hum.2016.147

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