A model for predicting the risk of cancer consequent to retroviral gene therapy.

doi:10.1089/hum.1992.3.5-479

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Article

A model for predicting the risk of cancer consequent to retroviral gene therapy.

Human gene therapy - 1 Oct 1992

Moolten F L, Cupples L A

Abstract excerpt

Theoretical estimates of the risk of cancer resulting from accidental insertion of retroviral gene therapy vectors into oncogenically vulnerable genomic sites may prove an important supplement to experimentally derived data in estimating risk/benefit ratios for future gene therapy trials. We have...

Topics

Animals
Genetic Therapy
Genetic Vectors
Humans
Models, Statistical
Mutation
Neoplasms
Retroviridae
Risk

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