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Article

Picornavirus Modification of a Host mRNA Decay Protein

7 Nov 2012

Abstract excerpt

UNLABELLED: Due to the limited coding capacity of picornavirus genomic RNAs, host RNA binding proteins play essential roles during viral translation and RNA replication. Here we describe experiments suggesting that AUF1, a host RNA binding protein involved in mRNA decay, plays a role in the infectious cycle of picornaviruses such as poliovirus and human rhinovirus. We observed cleavage of AUF1 during poliovirus...

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PMID: 23131833
DOI: 10.1128/mbio.00431-12

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