Article
Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2008
Pino Maria S, Balsamo Michele, Di Modugno Francesca, Mottolese Marcella, Alessio Massimo, Melucci Elisa, Milella Michele, McConkey David J, Philippar Ulrike, Gertler Frank B, Natali Pier Giorgio, Nisticò Paola
Abstract excerpt
PURPOSE: hMena, member of the enabled/vasodilator-stimulated phosphoprotein family, is a cytoskeletal protein that is involved in the regulation of cell motility and adhesion. The aim of this study was to determine whether or not the expression of hMena isoforms correlated with sensitivity to EGFR tyrosine kinase inhibitors and could serve as markers with potential clinical use. EXPERIMENTAL DESIGN: Human...
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