Specific transgenerational imprinting effects of the endocrine disruptor methoxychlor on male gametes

doi:10.1530/rep-10-0400

Article

Specific transgenerational imprinting effects of the endocrine disruptor methoxychlor on male gametes

9 Nov 2010

Abstract excerpt

Endocrine-disrupting chemicals (EDCs), among which methoxychlor (MXC), have been reported to affect the male reproductive system. This study evaluates the possible deleterious effects of MXC on imprinted genes. After administration of the chemical in adult male mice or in pregnant mice we analyzed by pyrosequencing possible methylation defects in two paternally imprinted (H19 and Meg3 (Gtl2)) and three maternally...

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