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Article

Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver

3 Jul 2020

Abstract excerpt

Di-(2-ethylhexyl) phthalate (DEHP), a ubiquitous industrial pollutant, is a known endocrine disrupter implicated in metabolic diseases. Prenatal DEHP exposure promotes epigenetic multi- and transgenerational inheritance of adult onset disease in subsequent generations (F1-F3). However, the epigenetic toxicity is less understood in the liver. In this study, CD-1 mice were prenatally exposed to 20 μg/kg/day, 200...

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PMID: 32628958
DOI: 10.1016/j.taap.2020.115123

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