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Article

Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer.

Oncology reports - 1 Jan 2013

Hao Xiao-Dan, Yang Yue, Song Xin, Zhao Xue-Ke, Wang Li-Dong, He Jun-Dong, Kong Qing-Peng, Tang Nelson Leung Sang, Zhang Ya-Ping

Abstract excerpt

Genomic instability caused by telomere erosion is an important mechanism of tumorigenesis. p53 plays a key role in cellular senescence and/or apoptosis associated with telomere erosion which positions p53 as a guard against tumorigenesis. The present study was undertaken to investigate the potential interactions between p53 functional mutations, polymorphisms,...

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Identifiers

PMID: 23124483
DOI: 10.3892/or.2012.2098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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