Exonuclease VII is involved in "reckless" DNA degradation in UV-irradiated Escherichia coli.

doi:10.1016/j.mrgentox.2012.10.005

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Article

Exonuclease VII is involved in "reckless" DNA degradation in UV-irradiated Escherichia coli.

Mutation research - 20 Jan 2013

Repar Jelena, Briški Nina, Buljubašić Maja, Zahradka Ksenija, Zahradka Davor

Abstract excerpt

The recA mutants of Escherichia coli exhibit an abnormal DNA degradation that starts at sites of double-strand DNA breaks (DSBs), and is mediated by RecBCD exonuclease (ExoV). This "reckless" DNA degradation occurs spontaneously in exponentially growing recA cells, and is stimulated by DNA-damaging agents. We have previously found that the xonA and sbcD mutations, which inactivate exonuclease I (ExoI) and SbcCD...

Topics

DNA Breaks, Double-Stranded
DNA Fragmentation
DNA Repair
Escherichia coli
Escherichia coli Proteins
Exodeoxyribonucleases
Exonucleases
Mutation
Ultraviolet Rays

Source

Open in PubMed

Identifiers

PMID: 23123979
DOI: 10.1016/j.mrgentox.2012.10.005

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