Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterozygous mutations in the FGF8, SHH and nodal/transforming growth factor beta pathways do not confer increased dopaminergic neuron vulnerability--a zebrafish study.

Neuroscience letters - 4 Jan 2013

Lo Christine, Flinn Laura J, Bandmann Oliver

Abstract excerpt

Fibroblast growth factor 8 (FGF8), sonic hedgehog (SHH) and nodal signalling pathways play key roles in both development and survival of dopaminergic neurons. Both heterozygous mutations in autosomal recessively inherited Parkinson's disease (PD) genes such as parkin or PINK1 and exposure to exog...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dopaminergic Neurons
Share to Embryo, Nonmammalian
Share to Fibroblast Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Nodal Protein

Share to Zebrafish

Share to Zebrafish Proteins

Source

Identifiers

PMID: 23123778
DOI: 10.1016/j.neulet.2012.10.035

Genes

FGF8
SHH
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23123778-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterozygous mutations in the FGF8, SHH and nodal/transforming growth factor beta pathways do not confer increased dopaminergic neuron vulnerability--a zebrafish study.PMID 23123778Read ↗

Studying the Pathophysiology of Parkinson’s Disease Using ZebrafishSemantic proximity Read ↗

Early motor deficits, sleep dysfunction and reduction in dopaminergic neurons in a park7 -/- zebrafish larval model of Parkinson’s diseaseSemantic proximity Read ↗

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio)Semantic proximity Read ↗

A Critical Review of Zebrafish Models of Parkinson’s DiseaseSemantic proximity Read ↗

1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine induced Parkinson's disease in zebrafishSemantic proximity Read ↗

Modeling Parkinson’s Disease in ZebrafishSemantic proximity Read ↗

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Treated Adult Zebrafish as a Model for Parkinson’s DiseaseSemantic proximity Read ↗

The Influence of the Zebrafish Genetic Background on Parkinson's Disease–Related AspectsSemantic proximity Read ↗

Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement.Semantic proximity Read ↗

Zebrafish as a new animal model for movement disorders.Semantic proximity Read ↗

Loss of Panx1 Function in Zebrafish Alters Motor Behavior in a Lab-on-Chip Model of Parkinson's DiseaseSemantic proximity Read ↗

Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of<i>pink1</i>functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.