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Article

Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate.

Toxicology letters - 17 Dec 2012

Wlodarczyk Bogdan, Spiegelstein Ofer, Hill Denise, Le X Chris, Finnell Richard H

Abstract excerpt

In most mammalian species, arsenic biotransformation occurs primarily by biomethylation and reduction reactions, with dimethylarsinic acid being the predominant metabolite excreted in the urine. Methylenetetrahydrofolate reductase (Mthfr) plays a key role in folate metabolism by channeling one-carbon units between nucleotide synthesis and methylation reactions. In the study on transgenic Mtfhr knockout mice we...

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PMID: 23123153
DOI: 10.1016/j.toxlet.2012.10.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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