Article
Evaluation of IL-28B polymorphisms and serum IP-10 in hepatitis C infected chimpanzees.
PloS one - 1 Jan 2012
Verstrepen Babs E, de Groot Natasja G, Groothuismink Zwier M A, Verschoor Ernst J, de Groen Rik A, Bogers Willy M, Janssen Harry L A, Mooij Petra, Bontrop Ronald E, Koopman Gerrit, Boonstra Andre
Abstract excerpt
In humans, clearance of hepatitis C virus (HCV) infection is associated with genetic variation near the IL-28B gene and the induction of interferon-stimulated genes, like IP-10. Also in chimpanzees spontaneous clearance of HCV is observed. To study whether similar correlations exist in these animals, a direct comparison of IP-10 and IL-28B polymorphism between chimpanzees and patients was performed. All...
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