Article
DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia.
Journal of psychopharmacology (Oxford, England) - 1 Apr 2013
Lawford B R, Barnes M, Swagell C D, Connor J P, Burton S C, Heslop K, Voisey J, Morris C P, Nyst P, Noble E P, Young R M
Abstract excerpt
Although the advent of atypical, second-generation antipsychotics (SGAs) has resulted in reduced likelihood of akathisia, this adverse effect remains a problem. It is known that extrapyramidal adverse effects are associated with increased drug occupancy of the dopamine 2 receptors (DRD2). The A1 allele of the DRD2/ANKK1, rs1800497, is associated with decreased striatal DRD2 density. The aim of this study was to...
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