Article
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Cancer cell - 16 Oct 2012
Jiang Xi, Huang Hao, Li Zejuan, Li Yuanyuan, Wang Xiao, Gurbuxani Sandeep, Chen Ping, He Chunjiang, You Dewen, Zhang Shuodan, Wang Jinhua, Arnovitz Stephen, Elkahloun Abdel, Price Colles, Hong Gia-Ming, Ren Haomin, Kunjamma Rejani B, Neilly Mary Beth, Matthews Jonathan M, Xu Mengyi, Larson Richard A, Le Beau Michelle M, Slany Robert K, Liu Paul P, Lu Jun, Zhang Jiwang, He Chuan, Chen Jianjun
Abstract excerpt
Expression of microRNAs (miRNAs) is under stringent regulation at both transcriptional and posttranscriptional levels. Disturbance at either level could cause dysregulation of miRNAs. Here, we show that MLL fusion proteins negatively regulate production of miR-150, an miRNA widely repressed in acute leukemia, by blocking miR-150 precursors from being processed to mature miRNAs through MYC/LIN28 functional axis....
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