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Article

Phenotypic analysis of human CYP2C9 polymorphisms using fluorine-substituted tolbutamide.

Drug discoveries & therapeutics - 8 Sept 2020

Kitamura Yuki, Saeki Ken-Ichi

Abstract excerpt

To investigate the effect of fluorine substitution on tolbutamide (TB) hydroxylation catalyzed by CYP2C9, the hydroxylation of TB and its fluorinated derivative 3'-fluoro-tolbutamide (3'-F-TB) by recombinant human CYP2C9*1, CYP2C9*2, and CYP2C9*3 was analyzed. In general, fluorine substitution near the metabolic site may decrease enzymatic oxidation owing to its electron-withdrawing nature. Fluorine substitution...

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Share to Cytochrome P-450 CYP2C9
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Identifiers

PMID: 32863324
DOI: 10.5582/ddt.2020.03060

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