Article
CYP2C9 and VKORC1 gene polymorphism is inessential for bleeding development under conditions of oral application of anticoagulant acenocoumarol in Russian patients at high risk of thromboembolic complications.
Bulletin of experimental biology and medicine - 1 Oct 2012
Sychev D V, Ignatyev I V, Emelyanov N V, Milovanova V V, Kossovskaya A V, Kukes I V, Tashenova A I, Kukes V G
Abstract excerpt
The study included 52 patients at a high risk of thromboembolic complications, with permanent atrial fibrillation. All patients were treated with acenocoumarol for 6 months and the incidence of hemorrhages was evaluated in all of them. All patients were genotyped by CYP2C9 and VKORC1. The presence of CYP2C9*2 and CYP2C9*3 alleles of CYP2C9 locus and AA genotype of VCORC1 gene polymorphic G-1639(3673)A marker was...
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