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Article

Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia.

Human genetics - 1 Feb 2013

Nakayama Kazuhiro, Ogawa Ayumi, Miyashita Hiroshi, Tabara Yasuharu, Igase Michiya, Kohara Katsuhiko, Miki Tetsuro, Kagawa Yasuo, Yanagisawa Yoshiko, Katashima Mitsuhiro, Onda Tomohiro, Okada Koichi, Fukushima Shogo, Iwamoto Sadahiko

Abstract excerpt

Accumulation of visceral fat increases cardiovascular mortality in industrialized societies. However, during the evolution of the modern human, visceral fat may have acted as energy storage facility to survive in times of famine. Therefore, past natural selection might contribute to shaping the variation of visceral fat accumulation in present populations. Here, we report that the gene encoding tribbles homolog 2...

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Source

Identifiers

PMID: 23108367
DOI: 10.1007/s00439-012-1240-9

Genes

TRIB2

Provenance

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