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Article

Characterization of the effects of an rpoC mutation that confers resistance to the Fst peptide toxin-antitoxin system toxin.

Journal of bacteriology - 1 Jan 2013

Brinkman Cassandra L, Bumgarner Roger, Kittichotirat Weerayuth, Dunman Paul M, Kuechenmeister Lisa J, Weaver Keith E

Abstract excerpt

Overexpression of the Fst toxin in Enterococcus faecalis strain OG1X leads to defects in chromosome segregation, cell division and, eventually, membrane integrity. The M7 mutant derivative of OG1X is resistant to most of these effects but shows a slight growth defect in the absence of Fst. Full-genome sequencing revealed two differences between M7 and its OG1X parent. First, OG1X contains a frameshift mutation...

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Identifiers

PMID: 23104812
DOI: 10.1128/JB.01597-12
PMCID: PMC3536179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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