Article
Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.
PLoS genetics - 1 Jan 2012
Kuang Ersheng, Okumura Cheryl Y M, Sheffy-Levin Sharon, Varsano Tal, Shu Vincent Chih-Wen, Qi Jianfei, Niesman Ingrid R, Yang Huei-Jiun, López-Otín Carlos, Yang Wei Yuan, Reed John C, Broday Limor, Nizet Victor, Ronai Ze'ev A
Abstract excerpt
Autophagy is the mechanism by which cytoplasmic components and organelles are degraded by the lysosomal machinery in response to diverse stimuli including nutrient deprivation, intracellular pathogens, and multiple forms of cellular stress. Here, we show that the membrane-associated E3 ligase RNF5 regulates basal levels of autophagy by controlling the stability of a select pool of the cysteine protease ATG4B....
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