Article
CYP2C19 genotype has a major influence on labetalol pharmacokinetics in healthy male Chinese subjects.
European journal of clinical pharmacology - 1 Apr 2013
Chan Sze Wa, Hu Miao, Ko Sara Shun Wah, Tam Catherine Wing Yan, Fok Benny Siu Pong, Yin Ophelia Qi Ping, Chow Moses Sing Sum, Tomlinson Brian
Abstract excerpt
PURPOSE: The pharmacokinetics (PK) of labetalol show wide inter-subject variability, but the genetic causes for this are largely undetermined. This study was performed to examine whether common polymorphisms in UGT1A1, UGT2B7, CYP2C19 and ABCB1 affect the PK of labetalol. METHODS: The PK of labetalol were determined in 37 Chinese healthy male subjects who took a single oral dose of 200 mg labetalol. Plasma...
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