Article
Genetic linkage analysis in the presence of germline mosaicism.
Statistical applications in genetics and molecular biology - 4 Oct 2011
Weissbrod Omer, Geiger Dan
Abstract excerpt
Germline mosaicism is a genetic condition in which some germ cells of an individual contain a mutation. This condition violates the assumptions underlying classic genetic analysis and may lead to failure of such analysis. In this work we extend the statistical model used for genetic linkage analysis in order to incorporate germline mosaicism. We develop a likelihood ratio test for detecting whether a genetic...
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