Genetic linkage analysis in the presence of germline mosaicism.

doi:10.2202/1544-6115.1709

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Article

Genetic linkage analysis in the presence of germline mosaicism.

Statistical applications in genetics and molecular biology - 4 Oct 2011

Weissbrod Omer, Geiger Dan

Abstract excerpt

Germline mosaicism is a genetic condition in which some germ cells of an individual contain a mutation. This condition violates the assumptions underlying classic genetic analysis and may lead to failure of such analysis. In this work we extend the statistical model used for genetic linkage analysis in order to incorporate germline mosaicism. We develop a likelihood ratio test for detecting whether a genetic...

Topics

Alleles
Computational Biology
Computer Simulation
Genetic Diseases, Inborn
Genetic Linkage
Genetic Loci
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Models, Genetic
Pedigree
Polymorphism, Single Nucleotide
Reproducibility of Results
Sensitivity and Specificity

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Identifiers

PMID: 23089820
DOI: 10.2202/1544-6115.1709
PMCID: PMC3215430

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