Recurrence risk of a new dominant mutation in children of unaffected parents.

Abstract excerpt

Extensions to models originally described by Hartl for predicting the recurrence risk of new dominant mutations are developed in this paper. Additions to the models are (1) possible somatic mosaicism in a parent in some families, (2) the possibility that the parental origin of the mutation may or may not be known, and (3) mutation rates which change as a function of sex and/or time. The models indicate that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Germ Cells
• Share to Infant
• Share to Models, Genetic