Article
Incidence of the BRAF V600E mutation in chronic lymphocytic leukaemia and prolymphocytic leukaemia.
Leukemia research - 1 Apr 2012
Langabeer Stephen E, Quinn Fiona, O'Brien David, McElligott Anthony M, Kelly Johanna, Browne Paul V, Vandenberghe Elisabeth
Abstract excerpt
The spectrum of underlying molecular abnormalities of clinically and biologically heterogeneous chronic lymphocytic leukaemia (CLL) and prolymphocytic leukaemia (PLL) has yet to be identified. While whole genome sequencing has identified several genes implicated in the pathogenesis and progression of CLL, the molecular lesions in a substantial proportion of patients remain to be elucidated. The incidence of the...
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