Article
Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection.
Molecular biology of the cell - 1 Dec 2012
Panas Marc D, Varjak Margus, Lulla Aleksei, Eng Kai Er, Merits Andres, Karlsson Hedestam Gunilla B, McInerney Gerald M
Abstract excerpt
Dynamic, mRNA-containing stress granules (SGs) form in the cytoplasm of cells under environmental stresses, including viral infection. Many viruses appear to employ mechanisms to disrupt the formation of SGs on their mRNAs, suggesting that they represent a cellular defense against infection. Here, we report that early in Semliki Forest virus infection, the C-terminal domain of the viral nonstructural protein 3...
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